#High-ProteinDiet; #WeightLoss; #CardiovascularDisease; #Plaques; #Atherosclerosis
New York, Feb 15 (Canadian-Media): Although high-protein diets are useful for more weight loss, but recent research published in Nat. Metab. 2, 110 (2020) suggests increased incidence of cardiovascular disease, particularly atherosclerosis is associated with high dietary protein, science.sciencemag.org news reports said.
High-protein diet. Image credit: Twitter
When Zhang et al. fed a high-protein diet to pro-atherogenic mice by, they found that more atherosclerotic plaques formed.
It was also observed by them that the mammalian target of rapamycin (mTOR) were activated due to the high concentrations of amino acids in the blood of and resulted in the formation of atherosclerotic plaques.
Numerous amino acid–sensing pathways are integrated by mTOR, and its activation in macrophages leads to the accumulation of dysfunctional mitochondria and apoptosis.
Important mechanistic insight into how dietary nutrients can influence systemic homeostasis is provided by this research.